Baroreflex Control of Renal Sympathetic Nerve Activity in Hypertensive Miniature Swine

The baroreceptor reflex control of renal nerve activity was examined in seven normo-tensive and 14 deoxycorticosterone acetate-treated anesthetized Yucatan miniature swine. Pressor responses evoked by the administration of phenylephrine were used to assess reflex control. The mean absolute threshold...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1985-11, Vol.7 (6, Part 1), p.879-885
Main Authors: NOTVEST, RONALD R, ZAMBRASKI, EDWARD J
Format: Article
Language:English
Subjects:
Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Desoxycorticosterone
Experimental diseases
Hypertension - chemically induced
Hypertension - physiopathology
Kidney - innervation
Male
Medical sciences
Pressoreceptors - physiopathology
Reflex - physiology
Swine
Sympathetic Nervous System - physiopathology
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Summary:The baroreceptor reflex control of renal nerve activity was examined in seven normo-tensive and 14 deoxycorticosterone acetate-treated anesthetized Yucatan miniature swine. Pressor responses evoked by the administration of phenylephrine were used to assess reflex control. The mean absolute threshold for inhibition of renal nerve activity was higher but not significantly different between the deoxycorticosterone acetate-treated and normotensive group. However, the mean rela-tive threshold for inhibition of renal nerve activity was significantly greater in the deoxycorticosterone acetate-treated group (p < 0.05). Responses from five deoxycorticosterone acetate-treated and five normotensive swine were used to examine the time course of the baroreflex inhibition of renal nerve activity. During the initial rise in pressure the percent inhibition of renal nerve activity was similar for the two groups. During the recovery phase of the response, renal nerve activity in the deoxycortico-sterone acetate—treated group returned to baseline while renal nerve activity remained attenuated below baseline in the normotensive group. The gain of the reflex was significantly lower in the deoxycorticosterone acetate-treated group compared with the control group (p < 0.05). The results of this study clearly indicate that baroreceptor reflex control of renal nerve activity is altered in anesthe-tized deoxycorticosterone acetate-treated hypertensive swine.
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.7.6.879