Cardiac Output and Renal Blood Flow in Glycerol‐Induced Acute Renal Failure in the Rat

SUMMARYCardiac output (CO) and renal blood How (RBF) were simultaneously evaluated by the microsphere method in water-drinking and chronic saline-drinking rats at 3, 12, and 24 hours after induction of acute renal failure by glycerol injection. Three hours after glycerol injection CO and RBF decreas...

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Bibliographic Details
Published in:Circulation research 1977-02, Vol.40 (2), p.178-182
Main Authors: HSU, CHEN H, KURTZ, THEODORE W, WALDINGER, THOMAS P
Format: Article
Language:English
Subjects:
Acute Kidney Injury - blood
Acute Kidney Injury - chemically induced
Acute Kidney Injury - physiopathology
Animals
Blood Pressure
Blood Urea Nitrogen
Blood Volume
Cardiac Output
Dehydration
Disease Models, Animal
Drinking
Glycerol
Kidney - blood supply
Male
Rats
Regional Blood Flow
Sodium Chloride
Vascular Resistance
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Summary:SUMMARYCardiac output (CO) and renal blood How (RBF) were simultaneously evaluated by the microsphere method in water-drinking and chronic saline-drinking rats at 3, 12, and 24 hours after induction of acute renal failure by glycerol injection. Three hours after glycerol injection CO and RBF decreased to 36% and 20% of the respective controls in water-drinking rats and to 41% and 24% of the controls in saline-drinking rats. Renal vascular resistance (RVR) increased significantly in both groups at this time. Isoncotic plasma expansion (3% of body weight) restored the RBF and RVR to normal in water-drinking rats 3 hours post-glycerol injection, although CO increased to only 70% of the control. Twelve hours after glycerol injection, CO and RBF returned to normal in saline-drinking rats, whereas they remained lower than controls in water-drinking rats. Twenty-four hours post-glycerol injection, when acute renal failure was evident as indicated by blood urea nitrogen (BUN) values of 116.9 and 63.8 ing/100 ml in water- and saline-drinking rats, respectively, CO and RBF returned to normal, except that the CO of water-drinking rats was slightly higher than control. Thus, we conclude that decreased CO is an important determinant of the early decrease in renal perfusion in glycerol-induced acute renal failure. Furthermore, the observed earlier return of CO and RBF to normal in saline-drinking rats may be partly responsible for reducing the severity of acute renal failure.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.res.40.2.178