Low plasma antioxidant activity is associated with high lesion volume and neurological impairment in stroke

Oxidative stress is probably involved in neuronal damage induced by ischemia-reperfusion. The purpose of this study was to assess the role of antioxidant activity in cerebral ischemic stroke. Antioxidant activity of blood plasma and cerebrospinal fluid was assessed in 22 patients with cerebral hemis...

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Bibliographic Details
Published in:Stroke (1970) 2000, Vol.31 (1), p.33-39
Main Authors: LEINONEN, J. S, AHONEN, J.-P, LÖNNROT, K, JEHKONEN, M, DASTIDAR, P, MOLNAR, G, ALHO, H
Format: Article
Language:English
Subjects:
Adult
Aged
Antioxidants - metabolism
Biological and medical sciences
Biomarkers
Brain - pathology
Brain - physiopathology
Female
Humans
Male
Medical sciences
Middle Aged
Neurology
Oxidative Stress
Stroke - blood
Stroke - cerebrospinal fluid
Stroke - pathology
Stroke - physiopathology
Vascular diseases and vascular malformations of the nervous system
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Summary:Oxidative stress is probably involved in neuronal damage induced by ischemia-reperfusion. The purpose of this study was to assess the role of antioxidant activity in cerebral ischemic stroke. Antioxidant activity of blood plasma and cerebrospinal fluid was assessed in 22 patients with cerebral hemisphere infarction that was verified and quantified by MRI. Low total peroxyl radical trapping potential of plasma, but not of cerebrospinal fluid, was associated with high lesion volume and high neurological impairment assessed by scores on NIH Stroke Scale, Barthel Index, and Hand Motor Score tests. The plasma concentrations of ascorbic acid, alpha-tocopherol, and protein thiols were also associated with the degree of neurological impairment. These data suggest that the antioxidant activity of plasma may be an important factor providing protection from neurological damage caused by stroke-associated oxidative stress.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.31.1.33