Differential Effects of 17β-Estradiol on Function and Expression of Estrogen Receptor α, Estrogen Receptor β, and GPR30 in Arteries and Veins of Patients With Atherosclerosis

Venous complications have been implicated in the adverse effects of hormone replacement therapy. This study investigated acute effects of the natural estrogen, 17β-estradiol, on function, estrogen receptors/GPR30 expression, and kinase activation in vascular rings and cultured smooth muscle cells fr...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2007-06, Vol.49 (6), p.1358-1363
Main Authors: Haas, Elvira, Meyer, Matthias R, Schurr, Ulrich, Bhattacharya, Indranil, Minotti, Roberta, Nguyen, Hung H, Heigl, Andres, Lachat, Mario, Genoni, Michele, Barton, Matthias
Format: Article
Language:English
Subjects:
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Hormones. Endocrine system
Medical sciences
Pharmacology. Drug treatments
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Summary:Venous complications have been implicated in the adverse effects of hormone replacement therapy. This study investigated acute effects of the natural estrogen, 17β-estradiol, on function, estrogen receptors/GPR30 expression, and kinase activation in vascular rings and cultured smooth muscle cells from arteries and veins of patients with coronary artery disease. Changes in vascular tone of internal mammary arteries and saphenous veins exposed to the steroid were recorded. 17β-Estradiol caused concentration-dependent, endothelium-independent relaxation in arteries (P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.107.089995