Salt Sensitivity of Blood Pressure Is Associated With Polymorphisms in the Sodium-Bicarbonate Cotransporter

Previous studies have demonstrated that single nucleotide polymorphisms (SNPs) of the sodium-bicarbonate co-transporter gene (SLC4A5) are associated with hypertension. We tested the hypothesis that SNPs in SLC4A5 are associated with salt sensitivity of blood pressure in 185 whites consuming an isoca...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2012-11, Vol.60 (5), p.1359-1366
Main Authors: Carey, Robert M, Schoeffel, Cynthia D, Gildea, John J, Jones, John E, McGrath, Helen E, Gordon, Lindsay N, Park, Min Jeong, Sobota, Rafal S, Underwood, Patricia C, Williams, Jonathan, Sun, Bei, Raby, Benjamin, Lasky-Su, Jessica, Hopkins, Paul N, Adler, Gail K, Williams, Scott M, Jose, Pedro A, Felder, Robin A
Format: Article
Language:English
Subjects:
Adult
Aldosterone - blood
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - genetics
Blood Pressure - physiology
Body Mass Index
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Diet
Dose-Response Relationship, Drug
Female
Gene Frequency
Genetic Predisposition to Disease - genetics
Genotype
Humans
Hypertension - etiology
Hypertension - genetics
Hypertension - physiopathology
Logistic Models
Male
Medical sciences
Meta-Analysis as Topic
Middle Aged
Odds Ratio
Outcome Assessment (Health Care)
Polymorphism, Single Nucleotide
Renin - blood
Sodium Chloride, Dietary - administration & dosage
Sodium Chloride, Dietary - adverse effects
Sodium-Bicarbonate Symporters - genetics
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Summary:Previous studies have demonstrated that single nucleotide polymorphisms (SNPs) of the sodium-bicarbonate co-transporter gene (SLC4A5) are associated with hypertension. We tested the hypothesis that SNPs in SLC4A5 are associated with salt sensitivity of blood pressure in 185 whites consuming an isocaloric constant diet with a randomized order of 7 days of low Na (10 mmol/d) and 7 days of high Na (300 mmol/d) intake. Salt sensitivity was defined as a ≥7-mm Hg increase in mean arterial pressure during a randomized transition between high and low Na diet. A total of 35 polymorphisms in 17 candidate genes were assayed, 25 of which were tested for association. Association analyses with salt sensitivity revealed 3 variants that associated with salt sensitivity, 2 in SLC4A5 (P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.112.196071