A Trial of 2 Strategies to Reduce Nocturnal Blood Pressure in Blacks With Chronic Kidney Disease

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 2013-01, Vol.61 (1), p.82-88
• Main Authors: Rahman, Mahboob, Greene, Tom, Phillips, Robert A, Agodoa, Lawrence Y, Bakris, George L, Charleston, Jeanne, Contreras, Gabriel, Gabbai, Francis, Hiremath, Leena, Jamerson, Kenneth, Kendrick, Cynthia, Kusek, John W, Lash, James P, Lea, Janice, Miller, Edgar R, Rostand, Stephen, Toto, Robert, Wang, Xulei, Wright, Jackson T, Appel, Lawrence J
• Format: Article
• Language: English
• Subjects: African Americans; Aged; Aged, 80 and over; Antihypertensive Agents - administration & dosage; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - drug effects; Blood Pressure Monitoring, Ambulatory; Cardiology. Vascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Cross-Over Studies; Diltiazem - administration & dosage; Diltiazem - pharmacology; Drug Administration Schedule; Drug Therapy, Combination; Female; Glomerular Filtration Rate - drug effects; Heart Rate - drug effects; Humans; Hydralazine - administration & dosage; Hydralazine - pharmacology; Hypertension - complications; Hypertension - drug therapy; Male; Medical sciences; Middle Aged; Ramipril - administration & dosage; Ramipril - pharmacology; Renal Insufficiency, Chronic - complications; Treatment Outcome
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/HYPERTENSIONAHA.112.200477

The objective of our study was to determine the effects of 2 antihypertensive drug dose schedules (PM dose and add-on dose) on nocturnal blood pressure (BP) in comparison with usual therapy (AM dose) in blacks with hypertensive chronic kidney disease and controlled office BP. In a 3-period, crossover trial, former participants of the African American Study of Kidney Disease were assigned to receive the following 3 regimens, each lasting 6 weeks, presented in random orderAM dose (once-daily antihypertensive medications taken in the morning), PM dose (once-daily antihypertensives taken at bedtime), and add-on dose (once-daily antihypertensives taken in the morning and an additional antihypertensive medication before bedtime [diltiazem 60–120 mg, hydralazine 25 mg, or additional ramipril 5 mg]). Ambulatory BP monitoring was performed at the end of each period. The primary outcome was nocturnal systolic BP. Mean age of the study population (n=147) was 65.4 years, 64% were men, and mean estimated glomerular filtration rate was 44.9 mL/min per 1.73 m. At the end of each period, mean (SE) nocturnal systolic BP was 125.6 (1.2) mm Hg in the AM dose, 123.9 (1.2) mm Hg in the PM dose, and 123.5 (1.2) mm Hg in the add-on dose. None of the pairwise differences in nocturnal, 24-hour, and daytime systolic BP was statistically significant. Among blacks with hypertensive chronic kidney disease, neither PM (bedtime) dosing of once-daily antihypertensive nor the addition of drugs taken at bedtime significantly reduced nocturnal BP compared with morning dosing of antihypertensive medications.