Abstract 9322: Remnant Lipoproteinemia is a Predictor of Coronary Events in Patients with Coronary Artery Disease and Chronic Kidney Disease

• Published in: Circulation (New York, N.Y.) N.Y.), 2011-11, Vol.124 (suppl_21)
• Main Authors: Saito, Yukio, Nakamura, Takamitsu, Sugamata, Wataru, Deyama, Juntaro, Uematsu, Manabu, Sano, Keita, Fujioka, Daisuke, Kitta, Yoshinobu, Kawabata, Ken-ichi, Obata, Jun-ei, Kugiyama, Kiyotaka
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.124.suppl_21.A9322

Abstract only Although triglyceride (TG) levels are increased in chronic kidney disease (CKD), the independence of high TG levels as a risk for coronary events remains debatable. We have previously shown that remnant lipoproteins, one of TG-rich lipoproteins, is a strong risk for future coronary events independent of low HDL-C levels and high LDL-C levels in patients with coronary artery disease (CAD). Thus, this study examined predictive value of remnant lipoproteins for coronary events in CAD patients with CKD. Methods: Fasting serum levels of remnant lipoproteins (remnant-like lipoprotein particles cholesterol; RLP-C) were measured by an immunoseparation method in 229 patients with CAD and CKD (estimated GFR < 60 ml/min/1.73m 2 , excluding hemodialysis patients). All patients were prospectively followed up for a period of 18 months or until occurrence of one of following events: cardiac death, nonfatal myocardial infarction (MI), unstable angina requiring unplanned coronary revascularization or worsening heart failure requiring hospitalization. Results: During follow-up period, events occurred in 28 (37%) patients with higher levels of RLP-C (> 5.0 mg/dL, 75 th percentile of the distribution) (5 cardiac death, 4 MI, 15 unstable angina, 4 heart failure), while events occurred in 18 (11.7%) patients with lower RLP-C levels (< 5.0 mg/dL) (2 MI, 14 unstable angina, 2 heart failure) (p