Abstract 9718: Rising Antibiotic Resistance: Changes in Microbial Patterns in Cardiac Implantable Electronic Device Infections

• Published in: Circulation (New York, N.Y.) N.Y.), 2011-11, Vol.124 (suppl_21)
• Main Authors: Hansen, James C, Nayak, Hemal M, Moss, Joshua D, Beshai, John F, Metzl, Mark D, Lazar, Sorin, Burke, Martin C
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.124.suppl_21.A9718

Abstract only Introduction: As the number of cardiac implantable electronic devices (CIEDs) implanted has risen, so has the number of CIED infections requiring extraction. We evaluated the type and sensitivity of microbial pathogens associated with CIED infections over a 16-year period. Hypothesis: We hypothesized that antibiotic resistance in CIED infections has increased since 1995. Methods: We reviewed 202 cases of infected CIEDs requiring extraction. The database was divided into two groups: Group I included the years 1995-2002 and Group II included 2003-2010. Each case was classified as resistant or sensitive. Resistance was present if cultures revealed a methicillin- or vancomycin-resistant organism; otherwise the organism was classified as sensitive. Groups were compared using chi-square analysis, with a p-value < 0.05 considered statistically significant. Results: CIED pocket infection or erosion was present in 62.9% of cases, persistent bacteremia with or without obvious endocarditis in 28.7%, and both in 8.4%. Resistance was seen in 13.7% of cases (3/41) in Group I, increasing to 34.2% of cases (55/161) in Group II (p