Abstract P024: Skin Intrinsic Fluorescence is Independently Associated with Coronary Artery Disease in Individuals with Long Duration Type 1 Diabetes

• Published in: Circulation (New York, N.Y.) N.Y.), 2012-03, Vol.125 (suppl_10)
• Main Authors: Conway, Baqiyyah N, Aroda, Vanita R, Maynard, John D, Ratner, Robert E, Orchard, Trevor J
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.125.suppl_10.AP024

Abstract only Background: Advanced glycation end products (AGEs), thought to be a measure of cumulative glycemic exposure and glycemia-induced vascular damage, are increased both in renal disease and diabetes. As AGE formation increases the stiffness of the arterial wall and vascular matrix AGEs interfere with nitric oxide action, AGEs may be an important link between renal and coronary artery disease (CAD). Skin intrinsic fluorescence (SIF) is a noninvasive marker of AGEs. We sought to determine if SIF was associated with CAD in type 1 diabetes and whether this relationship was independent of renal function and renal disease. Methods: SIF was measured on the volar area of the forearm of 112 subjects from the Pittsburgh Epidemiology of Diabetes Complications study and 60 subjects from MedStar Health Research Institute when mean age and diabetes duration were 48 and 36years, respectively. CAD was defined as a history of myocardial infarction, bypass surgery/revascularization, percutaneous coronary intervention or stenosis >50%. Overt nephropathy (ON) was defined as albumin excretion rate > 200 µg/min, spot urine albumin/creatinine > 300 ug/mg, or history of dialysis/ renal transplant. Cumulative glycemic exposure (updated mean A1c) was determined by averaging HbA1c values collected over follow-up (mean of 18 years in EDC and 10.3 years in MedStar). SIF and serum creatinine were natural log transformed before analyses. Odds ratios (OR) are expressed as per standard deviation change in a given variable. Results: Of the 172 participants, 30 had CAD, with an equal number in each sex. SIF levels were higher in those with CAD (p