Abstract P028: Higher Waist Circumference Identifies Insulin Resistance in Middle-age African-American Women Compared to Standard Metabolic Waist Thresholds for Europeans

• Published in: Circulation (New York, N.Y.) N.Y.), 2012-03, Vol.125 (suppl_10)
• Main Authors: Harman, Jane L, Buxbaum, Sarah G, Hairston, Kristen G, Sumner, Anne E
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.125.suppl_10.AP028

Abstract only Introduction Waist circumference thresholds that predict insulin resistance (IR) or metabolic syndrome may differ by race and ethnicity. Notably, a recent analysis of data from young African American (AA) adults (age 35±8) indicated that for AA women, the waist circumference (WC) predicting the top tertile of IR (mean HOMA-IR=3.0) was higher (≥98cm) than the IDF and NCEP-ATPIII threshold (≥88cm) for central obesity of metabolic syndrome. Hypothesis This analysis tested the hypothesis that in middle-aged AA adults, the WC predicting IR would be similar to that found in young AA adults: in AA women, a higher WC would predict IR than the standard WC threshold for metabolic syndrome. Methods Participants were AA adults attending the first examination of the Jackson Heart Study (2000-2004). After restricting analysis to non-related persons, non-diabetic, ages 35-80, BMI 18.5-55, with non-missing HOMA-IR, the analytical data set comprised 2269 persons (1374 women); age 55±11 (mean±SD); HOMA-IR 3.6±2.2; BMI 31±6.4 kg/m 2 ; WC: women: 98.3±15.6cm, men: 100.2 ±13.7cm. By ROC analysis, WC was a significantly better predictor of HOMA-IR than BMI for women but not men, although the predictive Area Under the Curve (AUC) was greater for men than women for both variables: AUC for WC vs.BMI: 0.78 vs 0.77 for men (p=.13); 0.75 vs 0.72 for women (p