Abstract 18558: Characterization of Cx43-PKP2 Interaction by Direct Stochastic Optical Reconstruction Microscopy

Abstract only The cardiac intercalated disc is composed of 3 structures involved in the electrical and mechanical coupling of the cardiomyocytes: gap junctions, desmosomes and adherens junctions. Several studies suggest that these structures interact at the intercalated disc. In particular a crossta...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2012-11, Vol.126 (suppl_21)
Main Authors: Agullo-Pascual, Esperanza, Reid, Dylan, Rothenberg, Eli, Delmar, Mario
Format: Article
Language:English
Online Access:Get full text
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Summary:Abstract only The cardiac intercalated disc is composed of 3 structures involved in the electrical and mechanical coupling of the cardiomyocytes: gap junctions, desmosomes and adherens junctions. Several studies suggest that these structures interact at the intercalated disc. In particular a crosstalk between the desmosomal and gap junction proteins PKP2 and Cx43 has been demonstrated. To characterize the proximity of these two proteins we used a Duolink assay. With this method, we demonstrated that Cx43 and PKP2 reside in the periphery of the adult cardiac intercalated disc at distances
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.126.suppl_21.A18558