Abstract 18068: Basis for a Major Genetic Alteration in Essential Hypertension: Inherited Defect in RBC-K Function and Oxygen Transport

Abstract only For decades, the pathogenesis and management of hypertension have been focused on dietary salt consumption, low potassium (K) intake, or hormonal factors triggering elevation of BP. In this context, our description of an inherited defect in RBC-K transport serially recorded in hyperten...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2013-11, Vol.128 (suppl_22)
Main Authors: Delgado-Almeida, Antonio R, Delgado-Lelievre, Maria C
Format: Article
Language:English
Online Access:Get full text
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Summary:Abstract only For decades, the pathogenesis and management of hypertension have been focused on dietary salt consumption, low potassium (K) intake, or hormonal factors triggering elevation of BP. In this context, our description of an inherited defect in RBC-K transport serially recorded in hypertensive subjects and in 52% of their normotensive adolescents offspring implies a genetic defect from erythropoietic cells and a biochemistry abnormalities in the circulating RBC as K-dependent pyruvate kinase activity for ATP synthesis, or allosteric K-O2 binding by hemoglobin, recently described by our Laboratory. Methods: A pedigree analysis was performed in randomized hypertensive patients (HT, aged ≥30-years) with essential hypertension (BP>140/90 mmHg), confirmed in the last 3-years, and having low RBC K content (
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.128.suppl_22.A18068