Abstract 18541: Morning Surge of Ventricular Arrhythmias in a New Arrhythmogenic Canine Model of Heart Failure is Associated With Attenuation of Heart Rate and Autonomic Adaptation but Reduced Cardiac Chaos

• Published in: Circulation (New York, N.Y.) N.Y.), 2013-11, Vol.128 (suppl_22)
• Main Authors: Zhu, Yujie, Hanafy, Mohamed A, Killingsworth, Cheryl R, Walcott, Gregory P, Young, Martin E, Pogwizd, Steven M
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.128.suppl_22.A18541

Abstract only Introduction: Ventricular arrhythmias in heart failure (HF) can be modulated by autonomic stimulation that is reflected by heart rate variability (HRV). Noninvasive measures of nonlinear dynamics (NLD) assess cardiac chaos, decrease of which can be detrimental in patients with HF. Holter monitoring of HF patients (to assess HRV & NLD) is limited by concurrent medication use. The aim of this study was to assess arrhythmia development, heart rate (HR) dynamics and nonlinear dynamics in a new arrhythmogenic canine model of HF. Methods: HF was induced in dogs (N=25) by aortic insufficiency & aortic constriction and assessed by echocardiography. Holter monitoring was performed to study time-of-day variation in arrhythmias (PVCs, VT), traditional HRV measures, and nonlinear dynamics (including Shannon entropy (SE), detrended fluctuations analysis α1 and α2 (DFAα1 & DFAα2), and correlation dimension (CD)) at baseline, 240 days (240d) and 720 days (720d) after HF induction. Results: LV fractional shortening decreased from 43.4±0.7 vs 27.5±0.8 % (p