Abstract 13: Detection of Abnormal Glucose Tolerance Status in Africans is improved by combining A1C with Fasting Glucose

Abstract only Diabetes is reaching epidemic proportions in Africa. Therefore it is critical to invest scarce resources in effective tests. Both the World Health Organization and the American Diabetes Association have approved A1C and fasting plasma glucose (FPG) as diagnostic alternatives to the OGT...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2014-03, Vol.129 (suppl_1)
Main Authors: Sumner, Anne E, Thoreson, Caroline K, O'Connor, Michelle Y, Ricks, Madia, Chung, Stephanie T, Lozier, Jay, Sacks, David B
Format: Article
Language:English
Online Access:Get full text
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Summary:Abstract only Diabetes is reaching epidemic proportions in Africa. Therefore it is critical to invest scarce resources in effective tests. Both the World Health Organization and the American Diabetes Association have approved A1C and fasting plasma glucose (FPG) as diagnostic alternatives to the OGTT for the detection of pre-diabetes and diabetes. However, A1C thresholds for the diagnosis of abnormal glucose tolerance are dependent on >90% of hemoglobin (Hb) being HbA. This could be problematic for Africans, as the prevalence of variant Hb including both sickle (S) and HbC are high. When either HbS or HbC is present as a trait, the concentration of HbA is usually
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.129.suppl_1.13