Abstract 19096: D-dimer Profile and Prognostic Implication in Different Classes of Acute Aortic Syndromes

Abstract only Background: D-dimer has been reported to be elevated at presentation in acute aortic dissection (AAD). However, little is known about D-dimer in the setting of intramural hematoma (IMH) and penetrating aortic ulcer (PAU) as well as its time course during hospitalization. Methods: Clini...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2014-11, Vol.130 (suppl_2)
Main Authors: Gorla, Riccardo, Janosi, Rolf A, Kahlert, Philipp, Tsagakis, Konstantinos, Jacob, Heinz, Bossone, Eduardo, Erbel, Raimund
Format: Article
Language:English
Online Access:Get full text
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Summary:Abstract only Background: D-dimer has been reported to be elevated at presentation in acute aortic dissection (AAD). However, little is known about D-dimer in the setting of intramural hematoma (IMH) and penetrating aortic ulcer (PAU) as well as its time course during hospitalization. Methods: Clinical and laboratory data of 300 patients with acute aortic syndromes (208 AAD, 45 IMH and 47 PAU) were prospectively collected from 2000 to 2014. D-dimer blood levels were measured at presentation and daily during hospitalization with a latex-enhanced turbidometric test (250 μg/l upper limit of normal; D-dimer Plus - Dade Behring) until 2009 and with a microparticle-enhanced immunoassay (0,55 mg/l upper limit of normal; Innovance - Dade Behring) from 2010. Analysis of variance with Bonferroni post hoc analysis and Student T test were applied as appropriate. Results: At presentation, AAD and IMH showed significantly higher D-dimer levels than PAU (p
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.130.suppl_2.19096