Abstract 11522: Does Neointimal Pattern Predict Instent Thrombus

• Published in: Circulation (New York, N.Y.) N.Y.), 2015-11, Vol.132 (Suppl_3 Suppl 3), p.A11522-A11522
• Main Authors: Gao, Lei, Lee, Stephen, Kim, Chong-Jin, Minami, Yoshiyasu, Ong, Daniel S, Soeda, Tsunenari, Lowe, Harry, Choi, So-Yeon, Lerman, Amir, Lee, Jay, Lee, Hang, Uemura, Shiro, Jang, Ik-Kyung
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.132.suppl_3.11522

IntroductionLocal determinants of instent thrombus formation after drug-eluting stent (DES) implantation have not been systematically investigated.HypothesisCertain neointimal patterns assessed by optical coherence tomography (OCT) may represent local surface thrombogenesity after DES implantation.MethodsA total of 208 patients with 262 DES who underwent follow-up OCT examination 11 months after DES implantation were studied. The detailed OCT findings including characteristics of neointima, lumen size, and stent morphology were compared between the group with and without thrombus.ResultsThrombus was identified in 11.5% (24/208) of the patients. Lipid-laden neointima, thin-cap fibroatheroma, heterogeneous neointima, and extra-stent lumen were more frequently detected in the thrombus group compared to the non-thrombus group (Figure). No difference was found in the % of uncovered (4.9±6.7% vs. 4.2±5.4%; p=0.575) or malapposed struts (1.5±2.5% vs. 0.8±2.1%; p=0.116) between the two groups. Minimal lumen cross sectional area was significantly smaller in the thrombus group compared with the non-thrombus group (2.9±1.7mm vs. 4.6±2.0mm; p