Abstract 11744: The Association Between Plasma Levels of Anti-angiogenic Isoform of Vascular Endothelial Growth Factor and Clinical Profiles of Peripheral Artery Disease

BackgroundAlthough circulating levels of vascular endothelial growth factor (VEGF), known as a stimulator of angiogenesis, were elevated in peripheral artery disease (PAD), patients with PAD is often associated with poor collateral formation, resulting in critical limb ischemia. Recently, it has bee...

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Published in:Circulation (New York, N.Y.) N.Y.), 2015-11, Vol.132 (Suppl_3 Suppl 3), p.A11744-A11744
Main Authors: Sato, Akihiko, Yoshihisa, Akiomi, Kanno, Yuki, Takiguchi, Mai, Miura, Shunsuke, Shimizu, Takeshi, Nakamura, Yuichi, Yamauchi, Hiroyuki, Owada, Takashi, Abe, Satoshi, Suzuki, Satoshi, Oikawa, Masayoshi, Sakamoto, Nobuo, Yamaki, Takayoshi, Sugimoto, Koichi, Kunii, Hiroyuki, Nakazato, Kazuhiko, Suzuki, Hitoshi, Saitoh, Shu-ichi, Takeishi, Yasuchika
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Language:English
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Summary:BackgroundAlthough circulating levels of vascular endothelial growth factor (VEGF), known as a stimulator of angiogenesis, were elevated in peripheral artery disease (PAD), patients with PAD is often associated with poor collateral formation, resulting in critical limb ischemia. Recently, it has been reported that VEGF165b, a major splicing variant of human VEGF-A, inhibits angiogenesis in some types of cancer and acts as anti-angiogenic. However, the association between circulating levels of VEGF165b and clinical manifestation of patients with PAD has not been fully examined.Methods and ResultsThis study included 45 patients with PAD who received endovascular therapy and 20 control subjects without PAD in our hospital. PAD was diagnosed according to the PAD management guidelines, such as computed tomography, angiography, and/or ankle-brachial index. We excluded patients with malignancy, end-stage renal disease on dialysis, severe chronic respiratory failure, and active inflammatory disease in consideration of influence on concentrations of VEGF. We measured circulating concentrations of VEGF165b in peripheral blood samples using enzyme-linked immunosorbent assay (ELISA). Plasma levels of VEGF165b were significantly higher in the PAD group than in the control group (91.7 ± 47.8 pg/ml vs. 30.4 ± 18.3 pg/ml, P
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.132.suppl_3.11744