Abstract 12000: Altered Vascular Elasticity Reflected Vascular Endothelial Dysfunction and Elevated Galectin-3 Using Novel Brachial Artery Vascular Volume Elastic Modulus With Automated Oscillometric Approach

• Published in: Circulation (New York, N.Y.) N.Y.), 2015-11, Vol.132 (Suppl_3 Suppl 3), p.A12000-A12000
• Main Authors: Yoshinaga, Keiichiro, Tomiyama, Yuuki, Fujii, Satoshi, Nishio, Saori, Ochi, Noriki, Katoh, Chietsugu, Inoue, Mamiko, Nishida, Mutumi, Takeuchi, Keisuke, Ito, Yoichi M, Tamaki, Nagara
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.132.suppl_3.12000

IntroductionSimple vascular function measurements are desirable for atherosclerosis risk assessments. Recently, we developed a novel modality of automated oscillometric method to measure a brachial artery’s vascular elastic modulus (VE) and reported that VE is uninfluenced by blood pressure. Galectin-3 (Gal-3) expressed in endothelial cells regulates vascular fibrosis and is a molecular determinant of vascular stiffness.HypothesisWe aimed to clarify whether VE selectively correlates with marker of vascular stiffness in chronic kidney disease (CKD).Methods12 moderate-to-severe CKD pts (mean eGFR 25.9±23.5 mL/min/1.73m) and 15 controls were studied. Rest VE in brachial artery was measured by new automated oscillometric detector. VE was defined as follows [VE =ΔPressure/ (100XΔarea/Area) mmHg/%]. Using ultrasound, the brachial artery diameter at rest and during reactive hyperemia [flow mediated dilatation (FMD) with endothelial-dependent dilatation] was measured. Gal-3 and interleukin-6 (IL-6), a representative inflammatory marker, were measured by enzyme-linked immune assay.ResultsCKD had lower FMD (4.86±3.37 vs 9.05±2.98 %, P=0.003) and had attenuated VE than control (1.08±0.26 vs 0.83±0.17 mmHg/%, P=0.002). CKD had higher IL-6 (0.67±0.29 vs 0.29±0.33 pg/mL, P=0.003) and higher Gal-3 (20.0±12.4 vs. 5.84±2.83 pg/mL, P