Abstract 13731: Activation of Focal Adhesion Kinase Leads to the Development and Progression of Abdominal Aortic Aneurysm in Mice

IntroductionAbdominal aortic aneurysms (AAAs) are characterized by chronic inflammation, which contributes to the pathological remodeling of extracellular matrix. Focal adhesion kinase (FAK) is involved in the interactions between cells and extracellular matrix, and has been suggested to regulate th...

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Published in:Circulation (New York, N.Y.) N.Y.), 2015-11, Vol.132 (Suppl_3 Suppl 3), p.A13731-A13731
Main Authors: Harada, Takasuke, Yoshimura, Koichi, Yamashita, Osamu, Ueda, Koshiro, Morikage, Noriyasu, Hamano, Kimikazu
Format: Article
Language:English
Online Access:Get full text
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Summary:IntroductionAbdominal aortic aneurysms (AAAs) are characterized by chronic inflammation, which contributes to the pathological remodeling of extracellular matrix. Focal adhesion kinase (FAK) is involved in the interactions between cells and extracellular matrix, and has been suggested to regulate the remodeling of extracellular matrix.HypothesisWe assessed the hypothesis that FAK plays a pivotal role in the development of AAA.Methods and ResultsAortic wall specimens were obtained from patients that underwent aortic surgery (AAA; n=25, non-AAA; n=8). Levels of activated FAK were significantly increased in AAA walls compared with non-AAA walls (2.8 ± 2.3 fold, p
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.132.suppl_3.13731