Abstract 14728: Atrial Fibrillation After Orthotopic Heart Transplantation: Results From a Meta-analysis

• Published in: Circulation (New York, N.Y.) N.Y.), 2015-11, Vol.132 (Suppl_3 Suppl 3), p.A14728-A14728
• Main Authors: Metz, Tamara, Mohanty, Sanghamitra, Mohanty, Prasant, Trivedi, Chintan, Gianni, Carola, Di Biase, Luigi, Natale, Andrea
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.132.suppl_3.14728

BackgroundAtrial fibrillation (AF) is a known complication of orthotopic heart transplantation (OHT). However, post-OHT AF is yet to be well characterized as studies report diverse data on the incidence rate and clinical characteristics of this arrhythmia. This study provides a review and meta-analysis of the existing evidences on the incidence rate, time of onset and association with allograft rejection of post-OHT AF.MethodsAn extensive literature search was performed on PubMed, MEDLINE and EMBASE databases (from 1990 to August 2014) and reference lists of selected articles for studies on the incidence of atrial fibrillation in OHT patients. Post OHT arrhythmia incidence data along with population characteristics were collected and pooled prevalence rate and associated 95% confidence intervals (CIs) were calculated.ResultsTen prospective studies with 3,852 patients undergoing OHT were included in the primary meta-analysis. The pooled prevalence of AF across studies was 5.4% (95% CI 7.0-10.1). AF was the most common early arrhythmia; 74% (95% CI 65-83) of the reported AF episodes were observed in