Abstract 16903: Prognostic Value of Combined CT Angiography and Myocardial Perfusion Imaging vs. Invasive Coronary Angiography and Nuclear Stress Perfusion Imaging for Predicting Major Adverse Cardiovascular Events - The CORE320 Multicenter Study

• Published in: Circulation (New York, N.Y.) N.Y.), 2015-11, Vol.132 (Suppl_3 Suppl 3), p.A16903-A16903
• Main Authors: Chen, Marcus Y, Rochitte, Carlos E, Arbab-Zadeh, Armin, Dewey, Marc, George, Richard T, Miller, Julie M, Niinuma, Hiroyuki, Yoshioka, Kunihiro, Kitagawa, Kakuya, Nakamori, Shiro, Laham, Roger, Vavere, Andrea L, Cerci, Rodrigo J, Mehra, Vishal C, Nomura, Cesar, Kofoed, Klaus F, Jinzaki, Masahiro, Kuribayashi, Sachio, de Roos, Albert, Laule, Michael, Tan, Swee Yaw, Hoe, John, Paul, Narinder, Rybicki, Frank J, Brinker, Jeffery A, Arai, Andrew E, Cox, Christopher, Clouse, Melvin E, Di Carli, Marcelo F, Lima, Joao A
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.132.suppl_3.16903

BackgroundNoninvasive risk stratification in patients with suspected coronary artery disease (CAD) is critical for implementing appropriate strategies to prevent major adverse events (MACE). We aim to compare the survival and accuracy of combined CT angiography (CTA) and CT myocardial stress perfusion imaging (CTP) with combined invasive coronary angiography (ICA) and stress SPECT myocardial perfusion imaging for predicting MACE in patients with suspected CAD.MethodsThe CORE320 prospective multicenter study enrolled 381 patients, between 45-85 years of age, who were clinically referred for ICA. Overall, 379 participants had all imaging including coronary CTA, adenosine stress CTP, SPECT and ICA plus complete 2 year follow-up data. An independent panel adjudicated all adverse events. MACE was defined as late revascularization (beyond 30 days of index ICA), myocardial infarction, cardiac death, hospitalization for chest pain or congestive heart failure, and arrhythmia. Kaplan-Meier survival analysis was performed and area under the receiving operating characteristic curve (AUC) was used to determine test accuracy.ResultsMACE (45 late revascularizations, 5 myocardial infarctions, 1 cardiac death, 8 hospitalizations for chest pain or congestive heart failure, and 1 arrhythmia) occurred in 51 of 379 patients. The 2 year MACE event free rate for combined CTA/CTP findings was 95% (-) vs. 82% (+) (Figure, p