Abstract MP55: Systemic Arterial Compliance Predicts All-cause Mortality and Cardiovascular Mortality: The Rancho Bernardo Study

• Published in: Circulation (New York, N.Y.) N.Y.), 2016-03, Vol.133 (suppl_1)
• Main Authors: Daka, Bledar, Langer, Robert D, Allison, Matthew, Lindblad, Ulf, Dandolu, Vani, Barrett-Connor, Elizabeth
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.133.suppl_1.mp55

Abstract only Objective: To investigate the association between peripherally measured arterial compliance and cardiovascular and total mortality in an elderly cohort. Background: There is limited evidence that systemic indices of elasticity and stiffness in the carotid and femoral arteries can predict incident cardiovascular disease (CVD) events. Little is known about the associations between systemic arterial compliance and CVD events. Methods: Between 1997 and 1999, 849 community dwelling participants in the Rancho Bernardo Study (mean age 74, 39% male, 4.2% with type 2 diabetes) underwent noninvasive pulse wave measurements. Systemic and brachial artery compliance were estimated using the PulseMetric device applying an algorithm previously validated by angiography. Data on cardiovascular risk factors and fasting blood samples were obtained at the same visit as the compliance measurements, as well as at a follow-up visit conducted within one year. CVD and overall mortality were recorded through January 2013. Kaplan-Meier survival curves for quartiles of systemic and brachial artery compliance were constructed. Cox proportional hazards models were used to examine the associations of systemic and brachial artery compliance with all-cause and CVD mortality. Multivariable models were used to assess interactions and to estimate the role of potential confounders. Stratified models were constructed when interactions of p