Abstract 16664: Intrapatient Variability in the Brockenbrough-Braunwald-Morrow Sign and Peak Instantaneous Left Ventricular Outflow Gradients in Obstructive Hypertrophic Cardiomyopathy

IntroductionAlthough the variability in left ventricular outflow tract (LVOT) gradients in patients with hypertrophic cardiomyopathy (HCM) is well known, the value of pulse pressure (PP) changes with ectopy for predicting changes in LVOT gradient remains unreported.HypothesisThis study examines the...

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Published in:Circulation (New York, N.Y.) N.Y.), 2018-11, Vol.138 (Suppl_1 Suppl 1), p.A16664-A16664
Main Authors: Bauch, Terry D, Smith, Alexandra J, Watts, James A, Rubal, Bernard J, Murgo, Joseph P
Format: Article
Language:English
Online Access:Get full text
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Summary:IntroductionAlthough the variability in left ventricular outflow tract (LVOT) gradients in patients with hypertrophic cardiomyopathy (HCM) is well known, the value of pulse pressure (PP) changes with ectopy for predicting changes in LVOT gradient remains unreported.HypothesisThis study examines the intrapatient variability in peak instantaneous LVOT gradients and aortic pulse pressure (PP) associated with the Brockenbrough-Braunwald-Morrow sign (BBM sign) compared with beat-to-beat variability.MethodsVariability in continuously recorded, high-fidelity left ventricular and aortic pressure waveforms were evaluated by computer-aided analysis in the resting state (N = 659 beats) and during supine exercise (N = 379 beats) in a symptomatic patient with a resting LVOT gradient >30 mmHg.ResultsBBM sign was observed in 92.9% (26/28) of post-PVC beats at rest and the post PVC PP decreased 11.8±8.2% (P
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.138.suppl_1.16664