Abstract 17005: Racial Differences in Mortality in Patients With Severe Aortic Stenosis After Aortic Valve Replacement

• Published in: Circulation (New York, N.Y.) N.Y.), 2018-11, Vol.138 (Suppl_1 Suppl 1), p.A17005-A17005
• Main Authors: White Solaru, Khendi T, Popovic, Zoran, Kalahasti, Vidyasagar, Roselli, Eric, Barzilai, Benico
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.138.suppl_1.17005

IntroductionAortic valve replacement (AVR) improves survival in patients with aortic stenosis (AS) or congenital bicuspid AV (BAV). To the authors’ knowledge, there are no studies that have examined racial differences in mortality after AVR for patients with severe AS or BAV. It is unknown whether AA patients undergoing AVR have worse outcomes and if they are impacted by confounding variables such as socioeconomic status.HypothesisWe sought to identify clinical characteristics in African Americans (AAs) and Whites who had AVR for severe AS. We hypothesized that there would be significantly higher mortality in AAs that would diminish after adjusting for differences in socioeconomic status and prevalence of other clinical characteristics such as hypertension and LV hypertrophy.MethodsRetrospective analysis was performed on 10,299 AA or Caucasian patients with severe AS or BAV treated at Cleveland Clinic with primary AVR from 1/1/2000 to 1/1/2017. Short- and long-term survival was assessed non-parametrically by the Kaplan-Meier method in both the unadjusted and matched groups. We used a propensity score strategy to match the two groups on a multitude of clinical and socioeconomic variables which yielded 201 matched pairs.ResultsMedian follow-up for death was 3.86 years. AAs had significantly higher short- and long- term mortality in the unadjusted analysis (p