Abstract 16591: The Impact of African Ancestry on the Pooled Cohort Equation Atherosclerotic Cardiovascular Disease Risk Estimation: Insights From the Hispanic Community Health Study/study of Latinos

ACC/AHA 2018 guidelines recommend using Non-Hispanic (NH)-White pooled cohort equations (PCE) to estimate 10-year risk of atherosclerotic cardiovascular disease (ASCVD) among Hispanics. If African ancestry is present, the PCE for Blacks is recommended. African ancestry estimates among Hispanic Commu...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2020-11, Vol.142 (Suppl_3 Suppl 3), p.A16591-A16591
Main Authors: Flores, Karen P, Khera, Amit, Sotres-Alvarez, Daniela, Mehta, Anurag, Pirzada, Amber, Swett, Katrina, DAVIGLUS, Martha L, C, Robert, Engel Gonzalez, Pedro, Gallo, Linda, Talavera, Gregory A, Sofer, Tamar, Joshi, Parag H, Rodriguez, Carlos J
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ACC/AHA 2018 guidelines recommend using Non-Hispanic (NH)-White pooled cohort equations (PCE) to estimate 10-year risk of atherosclerotic cardiovascular disease (ASCVD) among Hispanics. If African ancestry is present, the PCE for Blacks is recommended. African ancestry estimates among Hispanic Community Health Study/Study of Latinos (HCHS/SOL) background groups have been reported.1 We applied the PCE based on fractional African ancestry to HCHS/SOL participants and compared risk estimates from NH-White and NH-Black PCE in these groups. HCHS/SOL participants aged 40-75 years were divided into two groups based on median fractional African ancestry of ~10%groups with >=10% or higher African Ancestry (Puerto Rican, Central Americans, and Dominicans) and those with
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.142.suppl_3.16591