Abstract 10151: Association of Polygenic Risk Scores for Pre-Eclampsia and Blood Pressure with Hypertensive Pregnancy Disorders

• Published in: Circulation (New York, N.Y.) N.Y.), 2021-11, Vol.144 (Suppl_1), p.A10151-A10151
• Main Authors: Nurkkala, Jouko, Kauko, Anni, Laivuori, Hannele, Tanja, Saarela, Tyrmi, Jaakko, Cheng, Susan, Aittokallio, Jenni, Niiranen, Teemu
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.144.suppl_1.10151

IntroductionBlood pressure (BP) is a known risk factor for pre-eclampsia. We examined whether a BP-polygenic risk score (PRS) as compared with a pre-eclampsia-PRS, could also predict gestational hypertension (GHT), pre-eclampsia, and eclampsia. MethodsOur study sample included 116434 genotyped, previously-pregnant participants of the FinnGen cohort who were followed up between 1969-2019. PRSs for systolic BP and pre-eclampsia were derived using UK Biobank summary statistics for >1.1 million single nucleotide polymorphisms. ResultsWe observed 6561 cases of GHT, 5263 cases of pre-eclampsia, and 385 cases of eclampsia. As shown in the Figure, we observed that the BP-PRS was associated with GHT (multivariable-adjusted HR for 1-SD increase in PRS, 1.40; 95% CI, 1.36-1.43; p=9x10-160), pre-eclampsia (HR, 1.26 (95% CI 1.23-1.30, p=1.6x10-63) and with eclampsia (HR, 1.29 (95% CI, 1.16-1.42, p=8.1x10-7), respectively. The pre-eclampsia-PRS was also associated with GHT (HR, 1.09; 95% CI 1.07-1.12, p=1.0x10-12) pre-eclampsia (HR, 1.09; 95% CI, 1.06-1.12, p=2.2x10-10) and eclampsia (HR, 1.12, 95% CI, 1.02-1.24, p=0.023), although these associations were more modest. The model c-statistic for incident pre-eclampsia increased from 0.544 to 0.591 (95% CI for difference, 0.022-0.034, p