Abstract 10499: The Heart Failure-Induced Long Non-Coding RNA Heat4 Reduces the Inflammatory Response of Non-Classical Monocytes and Mediates Regeneration After Vascular Injury

Background and PurposeActivation of the immune system correlates with the severity and the prognosis of patients with heart failure (HF). This study aims to identify and characterize long non-coding RNAs (lncRNAs) as a potential mechanistic link between the pathophysiology of HF and the activation o...

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Published in:Circulation (New York, N.Y.) N.Y.), 2021-11, Vol.144 (Suppl_1), p.A10499-A10499
Main Authors: Kneuer, Jasmin M, Meinecke, Tim, Moebius-Winkler, Maximilian Nicolas, Weiss, Ronald, Haas, Jan, Garfias-Veitl, Tania, von Haehling, Stephan, Keller, Till, Thiele, Holger, Lurz, Philipp, Speer, Timo, Laufs, Ulrich, Boeckel, Jes-Niels
Format: Article
Language:English
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Summary:Background and PurposeActivation of the immune system correlates with the severity and the prognosis of patients with heart failure (HF). This study aims to identify and characterize long non-coding RNAs (lncRNAs) as a potential mechanistic link between the pathophysiology of HF and the activation of the immune system. Methods and ResultsUsing next-generation sequencing, we identified the lncRNA Heat4 to be 2-fold upregulated in the blood of patients with HF compared to controls (N=4; p
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.144.suppl_1.10499