Abstract 10694: Relationship of Serum Triglycerides with Incident End Stage Renal Disease Across Urine Albumin-to-Creatinine Ratio Subgroups and Chronic Kidney Disease Stages

• Published in: Circulation (New York, N.Y.) N.Y.), 2021-11, Vol.144 (Suppl_1), p.A10694-A10694
• Main Authors: Arif, Yousif, Soohoo, Melissa, Rizk, John, Hashemi, Leila, Marroquin, Maria, Hsiung, Jui-Ting, Edward, Jessica, Streja, Elani
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.144.suppl_1.10694

BackgroundStudies investigating serum triglycerides (TG) and renal outcomes including ESRD were mixed, and often these studies were unable to account for potential confounding for MetS components. It remains unclear how these relationships may present in patients with diabetic kidney disease and in consideration of albuminuria, or UACR. MethodsWe studied 138,675 US diabetic veterans, with data on serum TG and UACR from 2004-2006 and follow-up until 2014. Using Cox models adjusted for clinical characteristics and laboratory markers (including UACR, body mass index, hemoglobin A1c and high-density lipoprotein), we evaluated the relationship of baseline TG with time to ESRD. All models were stratified by baseline CKD stage and baseline albuminuria stage ascertained at time of TG measurement. ResultsThe cohort was 65±11 years old, and included 28% with CKD 3A-5, and 4% with UACR >300 mg/g. The median[IQR] of TG was 146[99,217] mg/dL. In non-albuminuric patients, we observed a linear relationship between TG and transition to ESRD among non-CKD patients, yet a U-shaped relationship for CKD 3A-3B (refTG 120-