Abstract 10709: Findings on Cardiology Screening Parameters for Cardiac Amyloidosis Differ Between African American and Non-African American Patients

• Published in: Circulation (New York, N.Y.) N.Y.), 2021-11, Vol.144 (Suppl_1), p.A10709-A10709
• Main Authors: Manjunath, Sonakshi, Deych, Elena, Lenihan, Daniel, Zhang, Kathleen
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.144.suppl_1.10709

IntroductionPrior studies have shown worse outcomes for African American (AA) patients with cardiac amyloidosis as compared to Caucasians. A potential contribution of diagnostic bias to delayed diagnosis of cardiac amyloidosis in AAs has not previously been explored. HypothesisStandard screening parameters for cardiac amyloidosis have worse diagnostic accuracy in AA as compared to non-AA patients. MethodsPatients evaluated at our institution from 2000-2018 for suspected cardiac amyloidosis with diagnostic confirmation by cardiac biopsy were included. Demographic, clinical and laboratory parameters at the time of evaluation were obtained, and ECGs and echocardiograms were analyzed by study personnel. Each parameter was compared between the biopsy positive and biopsy negative groups separately for AA and non-AA patients. ResultsAmong 223 patients with suspected cardiac amyloidosis, 90 were AA (64% biopsy positive) and 133 were non-AA (51% biopsy positive). Older age, low limb lead voltage, increased relative wall thickness, and apical sparing of longitudinal strain were associated with a positive biopsy in both AAs and non-AAs. Male gender, pseudoinfarct pattern, higher E/e’, and lower voltage-to-mass ratio were associated with a positive biopsy in non-AAs (p