Abstract 11446: The Role of Heart Rate Recovery in Chronic Heart Failure - Results from the Myovasc Study

• Published in: Circulation (New York, N.Y.) N.Y.), 2021-11, Vol.144 (Suppl_1), p.A11446-A11446
• Main Authors: Velmeden, David, Söhne, Jakob, Schuch, Alexander, Zeid, Silav, Schulz, Andreas, Troebs, Sven-Oliver, Müller, Felix, Heidorn, Marc, Buch, Gregor, Dinh, Wilfried, Lackner, Karl J, Gori, Tomaso, Muenzel, Thomas, Wild, Philipp S, Prochaska, Juergen
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.144.suppl_1.11446

BackgroundReduced heart rate recovery (HRR) has been associated with cardiac autonomic dysfunction, particularly the parasympathetic nervous system, and all-cause mortality in patients with heart failure (HF). MethodsIn the present study, data of the MyoVasc study (NCT04064450; N=3,289), a prospective cohort study on chronic HF, were analyzed. Participants received a comprehensive 5-hour examination in a dedicated study center including cardiopulmonary exercise testing (CPET) using modified WHO protocols. HRR60 was defined as the decrease in heart rate in beats per minute one minute after cessation of CPET peak strain. Information on clinical outcome (i.e. all-cause mortality, worsening of HF (wHF)) was derived from structured follow-up with subsequent validation and independent adjudication of endpoints. ResultsThe analysis sample comprised N=1,179 individuals (mean age65.0±10.4 years; 28.2% females) with data on HRR60. In a multivariable linear regression analysis, age (β-estimate -0.171 ([95% confidence interval -0.226; -0.116]; P