Abstract 13097: Diabetes and Obesity Are Causally Associated With Pulmonary Hypertension and Right Ventricular Function

• Published in: Circulation (New York, N.Y.) N.Y.), 2021-11, Vol.144 (Suppl_1), p.A13097-A13097
• Main Authors: Bagheri Naraghi, Minoo, Agrawal, Vineet, Annis, Jeffrey S, Ferguson, Jane F, Mosley, Jonathan D, Brittain, Evan L
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.144.suppl_1.13097

BackgroundObservational studies have shown overlap between pulmonary pressure, right ventricular (RV) function, and metabolic function, but causality has not been established. We used genetic variants associated with metabolic phenotypes to test for causality between metabolic function, pulmonary pressure, and RV function. MethodsWe included all European ancestry subjects in Vanderbilt University’s de-identified DNA biobank (BioVU) with an echo reporting pulmonary pressure (RVSP) and RV function (TAPSE). To investigate causal relationships, two-sample univariate and multivariate Mendelian Randomization (MR) analyses were conducted using genetic variants associated with phenotypes and echo measures. Significant phenotypes by univariate MR were included in multivariable MR models. We also tested echo measures for associations with polygenic risk scores (PRS) for metabolic phenotypes [score threshold5x10-8]. ResultsWe identified 17,221 men and women (mean age62yr) with RVSP and 6,209 men and women (mean age61yr) with TAPSE. Diabetes genetic risk was associated with higher RVSP (β=0.015, p=0.016) [Figure 1A] and lower TAPSE (β=-0.028, p