Abstract 9129: Effect of Cardiovascular Risk Factors on Hypertensive Disorders of Pregnancy: A Mendelian Randomization Study

• Published in: Circulation (New York, N.Y.) N.Y.), 2021-11, Vol.144 (Suppl_1), p.A9129-A9129
• Main Authors: Ardissino, Maddalena, Millar, Ophelia, Reddy, Rohin, Lazzari, Laura, Patel, Kiran, Ryan, David, Gill, Dipender, Johnson, Mark, Ng, Fu Siong
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.144.suppl_1.9129

IntroductionCardiovascular risk factors have been associated with adverse maternal and fetal outcomes, including risk of hypertensive disorders of pregnancy such as pre-eclampsia (PE) and low fetal birth weight. However, it is difficult to establish causal relationships from retrospective evidence due to risk of confounding. We applied Mendelian randomization to explore the role of traditional cardiovascular risk factors in determining maternal and fetal outcomes of pregnancy. MethodsSummary statistics were used to perform a 2-sample Mendelian randomization study to investigate the association of genetically-predicted systolic blood pressure (SBP), body mass index (BMI), glycated haemoglobin A1C (HbA1C), low-density lipoprotein cholesterol (LDL-C), and smoking with the primary outcome of pre-eclampsia or eclampsia in 1,689 cases and 52,576 controls of Finnish ancestry, and secondary outcome of birth weight of the first child of 145,558 European women from the UK Biobank. ResultsThere was a significant association between PE and both genetically-predicted SBP (OR per mmHg increase1.05,95%CI 1.01-1.10, p=0.030) and genetically-predicted BMI (OR per kg/m2 increase0.24 95%CI 1.07-1.90 p=0.017). Genetically-predicted SBP was associated with lower birth weight (OR per mmHg increase0.98, 95%CI 0.97-0.98 p