Abstract 11453: Age, Sex, and Outcomes in Heart Failure With Reduced Ejection Fraction: Insights From the VICTORIA Trial

BackgroundBoth patient age and sex influence heart failure (HF) treatment and outcomes. Given women are generally older in HF trials, we examined the associations of age and sex with clinical characteristics, background HF therapy, and response to vericiguat in VICTORIA. VICTORIA enrolled 5050 patie...

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Published in:Circulation (New York, N.Y.) N.Y.), 2022-11, Vol.146 (Suppl_1), p.A11453-A11453
Main Authors: Pina, Ileana L, Zheng, Yinggan, Bonderman, Diana, Pouleur, Anne, Saldariagga, Clara, Pieske, Burkert, Blaustein, Robert O, Nkulikiyinka, Richard, Westerhout, Cynthia M, Armstrong, Paul W, Lam, Carolyn S
Format: Article
Language:English
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Summary:BackgroundBoth patient age and sex influence heart failure (HF) treatment and outcomes. Given women are generally older in HF trials, we examined the associations of age and sex with clinical characteristics, background HF therapy, and response to vericiguat in VICTORIA. VICTORIA enrolled 5050 patients with HF with reduced ejection fraction (HFrEF) and recent worsening HF, was broadly inclusive without an upper age limit, and included 28% women (n=1208), and 31% (1568 ) were ≥75 years old with event rates exceeding most HF trials. MethodsClinical characteristics were compared across age groups (
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.146.suppl_1.11453