Abstract 15616: Single Cell Transcriptomic Profiling Identifies Ferroptosis and Oxidative Stress as Potential Drivers of Muscle Dysfunction in Pad

IntroductionPeripheral artery disease (PAD) affects >8 million people nationwide and is disabling. PAD-associated myopathy causes weakness yet is understudied. Unbiased transcriptomic profiling of muscle satellite cells (MuSC) which drive recovery may elucidate the etiology of ischemic myopathic...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2022-11, Vol.146 (Suppl_1), p.A15616-A15616
Main Authors: Tran, Lillian, Ferrari, Ricardo, Xie, Bowen, Assaf, Edwyn, Sachdev, Ulka
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:IntroductionPeripheral artery disease (PAD) affects >8 million people nationwide and is disabling. PAD-associated myopathy causes weakness yet is understudied. Unbiased transcriptomic profiling of muscle satellite cells (MuSC) which drive recovery may elucidate the etiology of ischemic myopathic change. HypothesisMuSC in PAD differentially express injury associated pathways that may be novel targets for intervention to reduce ischemic myopathy. MethodsMuscle tissue biopsies were obtained during lower extremity amputation or bypass in PAD/ischemic (N=4; ABI
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.146.suppl_1.15616