Abstract 9764: Simultaneous Assessment of Coronary Flow Reserve and Left Ventricular Strain During Vasodilator Stress Measured by 13 N-ammonia Positron Emission Tomography/Magnetic Resonance Imaging

• Published in: Circulation (New York, N.Y.) N.Y.), 2022-11, Vol.146 (Suppl_1)
• Main Authors: Kiko, Takatoyo, Endo, Keiichiro, Fukushima, Kenji, Takeishi, Yasuchika
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.146.suppl_1.9764

Abstract only Introduction: Hybrid positron emission tomography (PET)/magnetic resonance imaging (MRI) is able to yield important information regarding molecular and functional imaging in a one-stop examination. The aim of this study was to investigate the relationship between coronary flow reserve (CFR) and left ventricular longitudinal strain (LVLS) using simultaneous acquisitions on hybrid 13 N-ammonia PET/MRI. Methods: Thirty-eight patients with suspected coronary artery disease (CAD) who underwent 13 N-ammonia PET/MRI were enrolled. Vasodilator stress was induced by intravenous injection of adenosine. CFR was calculated from dynamic acquisition of 13 N-ammonia PET. LVLS was evaluated by feature-tracked MRI. Myocardial flow reserve (MFR) and LVLS values were based on a 17-segment model and three coronary territories, left anterior descending artery (LAD), left circumflex artery (LCx), and right coronary artery (RCA). Results: We analyzed 577 myocardial segments in the left ventricle. LVLS under vasodilator stress was significantly increased compared with LVLS at rest in myocardial segments with MFR ≥2.0 (P