Abstract P201: Plasma Proteomic Signatures of Angptl3/8 and 4/8 Before and After Exercise Training

• Published in: Circulation (New York, N.Y.) N.Y.), 2023-02, Vol.147 (Suppl_1), p.AP201-AP201
• Main Authors: Miranda-Maravi, Sebastian, Hoffman, William G, Dev, Prasun K, Barber, Jacob L, Schwartz, Charles S, Clarkson, William A, Robbins, Jeremy M, Rao, Prashant, Mi, Michael, Ghosh, Sujoy, Clish, Clary, Silbernagel, Gunther, Chen, Yan Q, Konrad, Robert J, Bouchard, Claude, Gerszten, Robert E, Sarzynski, Mark A
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.147.suppl_1.P201

IntroductionAngiopoietin like protein (ANGPTL) complexes 3/8 and 4/8 are established inhibitors of lipoprotein lipase and modifiable by regular exercise. However, the molecular biomarkers related to their exercise responses have not been fully elucidated. The purpose of this study was to examine the associations between plasma proteins and ANGPTL3/8 and 4/8 before and after exercise training. MethodsMeasurements were taken before and after 20 weeks of exercise training in 630 adults (36% Black, 56% women, mean age 35 yrs) of the HERITAGE Family Study. Meso Scale Discovery immunoassays were used to measure ANGPTL3/8 and ANGPTL4/8 complexes in serum. Plasma proteins (n=4979 aptamers) were quantified using SomaScan. Linear mixed models tested the association between plasma proteins and each trait at baseline and post- training with full covariate adjustment. Significance was set to FDR