Abstract 11964: The Effect of Endothelin-1 on Angiotensin II-Induced Renal Injury

Abstract only Introduction: Hypertension (HT) and kidney disease is increasingly recognized as a global public health problem. Angiotensin II (AngII) induces endothelin-1 (ET-1), and ET-1 is a key mediator of kidney fibrosis. Hypothesis: Inhibition of ET-1 may contribute to modulation of HT and rena...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2023-11, Vol.148 (Suppl_1)
Main Authors: Niida, Tomiharu, Isoda, Kikuo, Ohtomo, Fumie, Akita, Koji, Kitamura, Kenichi, Kadoguchi, Tomoyasu, Minamino, Tohru
Format: Article
Language:English
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Summary:Abstract only Introduction: Hypertension (HT) and kidney disease is increasingly recognized as a global public health problem. Angiotensin II (AngII) induces endothelin-1 (ET-1), and ET-1 is a key mediator of kidney fibrosis. Hypothesis: Inhibition of ET-1 may contribute to modulation of HT and renal injury induced by angiotensin II. Methods: In addition to wild-type (WT) mice, we also used IL-1 receptor antagonist-deficient (IL-1Ra -/- ) mice that were prone to AngII-induced renal inflammation, because WT (C57BL) mice were genetically resistant to renal injury in response to AngII. Both mice were infused with AngII (1000ng/kg/min) using subcutaneous osmotic pumps for 14 days. Results: Systolic blood pressure in IL-1Ra -/- mice significantly increased compared with WT mice (197±5 vs 169±9 mmHg, p
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.148.suppl_1.11964