Abstract 12170: The Impact of Frailty on Urea Metabolism in Tanushimaru Cohort Study

Abstract only Introduction: Urea metabolism activation, that is urea production, is thought to be very important as a body response for water retention in the process of human evolution. However, it is not clear how that body response is changing as aging. Previous metabolomics studies suggested tha...

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Published in:Circulation (New York, N.Y.) N.Y.), 2023-11, Vol.148 (Suppl_1)
Main Authors: Morikawa, Nagisa, Enomoto, Mika, Fukami, Ako, Sato, Hiromi, Yoshimura, Harumi, Adachi, Hisashi, Fukumoto, Yoshihiro, Takahashi, Kazuo, Kitada, Kento, Yano, Yuichiro, Nishiyama, Akira
Format: Article
Language:English
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Summary:Abstract only Introduction: Urea metabolism activation, that is urea production, is thought to be very important as a body response for water retention in the process of human evolution. However, it is not clear how that body response is changing as aging. Previous metabolomics studies suggested that various metabolites were influenced by frailty. Thus, we investigated the association between frailty and urea metabolism (urea cycle and TCA cycle) in this study. Methods: We recruited 976 participants who had a health check-up in 2009 and were followed in 2018 in the prospective Tanushimaru cohort study. We defined people with cognitive decline ((≧28 score of Mini-Mental State Examination (MMSE) in 2009 and 24-27 score in 2018), slow gait speed (
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.148.suppl_1.12170