Abstract 12513: Anti-Inflammatory Effect of Statin Among Patients With Rheumatoid Arthritis: A Network Meta-Analysis of Randomized Controlled Trials

• Published in: Circulation (New York, N.Y.) N.Y.), 2023-11, Vol.148 (Suppl_1)
• Main Authors: Jaiswal, Vikash, Jaiswal, Akash, Hanif, Muhammad, Jha, Mayank, Attia, Abdelrahman M, Gupta, Shiva, Ramadan, Alaa, Saleeb, Marina, Ang, Song Peng, Kalra, Kriti
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.148.suppl_1.12513

Abstract only Background: Rheumatoid arthritis (RA) have shown to be associated with a higher risk of acute coronary syndrome and atrial fibrillation. However, the impact of statin among RA patients is not well studied, with conflicting results. Objective: We aim to compare the anti-inflammatory effect of different statin drugs among patients with rheumatoid arthritis in this network meta-analysis (NMA). Methods: We performed a systematic literature search on the electronic database for relevant randomized controlled trials (RCTs) from inception until 25th May 2023. A network meta-analysis was conducted to evaluate the anti-inflammatory effect of different statin drugs among RA patients. We presented results as mean difference (MD) and 95% confidence interval. Results: A total of 16 RCTs with a total of 3,886 patients (1,938 in the statin group and 1,948 in the non-statin group) were included. The network meta-analysis showed that Atorvastatin was the only intervention that significantly decreased the mean difference of all the inflammatory predictors including ESR (MD= -6.77, 95% CI= [-9.52, -4.01], P