Abstract 12625: Characterising Mechanisms of Ischemia in Patients With Myocardial Bridges

Abstract only Background: Myocardial bridges (MB) have been associated with ischemic syndromes. Abnormal cardiac coronary coupling is implicated but has not been systematically evaluated. We sought to determine the substrates for ischemia in patients with angina, nonobstructive coronary arteries (AN...

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Published in:Circulation (New York, N.Y.) N.Y.), 2023-11, Vol.148 (Suppl_1)
Main Authors: Sinha, Aish, Rahman, Haseeb, Demir, Ozan, Rajani, Ronak, Gulati, Ankur, Li Kam Wa, Matthew, Morgan, Holly, Ezad, Saad, Ellis, Howard, Hogan, Dexter, Shah, Ajay M, Webb, Andrew, Marber, Michael, Perera, Divaka
Format: Article
Language:English
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Summary:Abstract only Background: Myocardial bridges (MB) have been associated with ischemic syndromes. Abnormal cardiac coronary coupling is implicated but has not been systematically evaluated. We sought to determine the substrates for ischemia in patients with angina, nonobstructive coronary arteries (ANOCA) and a MB in the left anterior descending artery. Methods: Patients with ANOCA underwent acquisition of intracoronary pressure and flow during rest, supine bicycle exercise and adenosine infusion. Coronary wave intensity analysis was performed, and perfusion efficiency defined as accelerating wave energy/total wave energy (%). Endothelial dysfunction was defined as a reduction in epicardial vessel diameter by >20% with intracoronary acetylcholine. Patients with ANOCA and a MB were compared to those with microvascular angina (CMD: coronary flow reserve, CFR,
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.148.suppl_1.12625