Abstract 13163: Clonal Hematopoiesis Risk Score is Associated With All-Cause and Cardiovascular Mortality in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study

Abstract only Introduction: Clonal hematopoiesis of indeterminate potential (CHIP) is common in older adults, but the prognostic significance is unknown. We studied the prevalence of CHIP and its mortality in older adults and investigated whether the CHIP risk score (CHRS) -tool to predict hematolog...

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Published in:Circulation (New York, N.Y.) N.Y.), 2023-11, Vol.148 (Suppl_1)
Main Authors: Saadatagah, Seyedmohammad, Uddin, Md Mesbah, Weeks, Lachelle D, Niroula, Abhishek, Ru, Meng, Takahashi, Koichi, Bradley, Steven, Yu, Bing, Bick, Alexander G, Ebert, Benjamin L, Platz, Elizabeth A, Natarajan, Pradeep, Ballantyne, Christie M
Format: Article
Language:English
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Summary:Abstract only Introduction: Clonal hematopoiesis of indeterminate potential (CHIP) is common in older adults, but the prognostic significance is unknown. We studied the prevalence of CHIP and its mortality in older adults and investigated whether the CHIP risk score (CHRS) -tool to predict hematologic malignancies (HM)- is associated with mortality in this population. Method: In ARIC cohort, CHIP was identified using exome sequencing, and CHRS scores were calculated using demographic, blood parameters, and molecular features. Individuals with CHIP were categorized into low- (CHRS≤9.5), intermediate- (9.5
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.148.suppl_1.13163