Abstract 14976: Proteomic Measures Linking Social Determinants of Health to Heart Failure Risk: The Atherosclerosis Risk in Communities Study

• Published in: Circulation (New York, N.Y.) N.Y.), 2023-11, Vol.148 (Suppl_1)
• Main Authors: Ramonfaur, Diego, Zierath, Rani, Lamberson, Victoria, Yang, Yimin, Claggett, Brian, Kucharska-Newton, Anna, Walker, Keenan A, Bhavsar, Nrupen A, Chang, Patricia, Diez Roux, Ana V, Bey, Ganga, Butler, Kenneth R, Ndumele, Chiadi E, Coresh, Josef, Floyd, James S, Odden, Michelle C, Shah, Amil M
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.148.suppl_1.14976

Abstract only Introduction: Adverse social determinants of health (SDOH) are risk factors for heart failure (HF), and both disproportionately burden Black adults. The mechanisms linking SDOH to incident HF are unclear. Methods: Among 9910 HF-free participants in the community-based ARIC study with proteomic data (Somascan v4) at Visit 3 (V3; 1993-95), we performed race-stratified (Black and non-Black race) analyses of the association of 4955 plasma proteins with SDOH and incident HF. We derived a SDOH factor based on income, education level, and neighborhood area deprivation index using exploratory factor analysis. We evaluated cross-sectional associations of the SDOH factor with proteins using age- and gender- adjusted linear regression at Bonferroni significance. The association of SDOH-associated proteins with incident HF during 10 years post-V3 was assessed using Cox PH regression further adjusting for cardiovascular co-morbidities, using an FDR