Abstract 15769: Ventricular Interdependent Phenotype of CPC-Pulmonary Hypertension With Normal Left Atrium and Pericardial Restraint: Impact on CPET Metrics and Clinical Outcomes

Abstract only Background: Combined pre- and post-capillary pulmonary hypertension (Cpc-PH) has overlapping pathophysiology due to left heart disease and pulmonary vascular disease, which may vary in an individual patient. Hypothesis: While the majority of CpcPH patients have left heart disease with...

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Published in:Circulation (New York, N.Y.) N.Y.), 2023-11, Vol.148 (Suppl_1)
Main Authors: Zampierollo-Jaramillo, Giovanna, Abed, Anas, Tu, Wanxin, Garcia-Arango, Mariana, ElShaer, Ahmed, Heffernan, Shannon, Esmaeeli, Amir, Runo, James, Masri, Sofia, Raza, Farhan
Format: Article
Language:English
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Summary:Abstract only Background: Combined pre- and post-capillary pulmonary hypertension (Cpc-PH) has overlapping pathophysiology due to left heart disease and pulmonary vascular disease, which may vary in an individual patient. Hypothesis: While the majority of CpcPH patients have left heart disease with abnormal left atrium, a minority of CpcPH patients have normal left atrium and develop elevated left-sided pressures due to exaggerated ventricular interdependence and pericardial restraint. Aim: to define ventricular interdependent sub-phenotype of CpcPH. Methods: 30 CpcPH patients undergoing invasive cardiopulmonary exercise test with complete echocardiographic data were identified. Abnormal left atrium group was defined as left atrial volume index ≥40mL/m 2 and E/E' ≥10, and rest was defined as normal left atrium group. p-value
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.148.suppl_1.15769