Abstract 16397: Inflammatory Biomarkers as Predictors of Systemic vs. Isolated Pocket Infection in Patients Undergoing Transvenous Lead Extraction

• Published in: Circulation (New York, N.Y.) N.Y.), 2023-11, Vol.148 (Suppl_1)
• Main Authors: Lacharite Roberge, Anne Sophie, Toomu, Sandeep, Aldaas, Omar, Ho, Gordon, Pollema, Travis L, Birgersdotter-Green, Ulrika
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.148.suppl_1.16397

Abstract only Intro: Cardiovascular implantable electronic device (CIED) infections are a common indication for device extraction. Early diagnosis and complete device and lead removal are crucial to reduce morbidity and mortality. The lack of clear infectious symptoms and signs make the diagnosis of CIED infections challenging and may delay referral for extraction. Methods: We performed a retrospective analysis of patients undergoing transvenous lead extraction for CIED infection at UCSD from 2012 to 2022 (n= 164). Our control group underwent extraction for non-infectious etiologies such as device malfunction, lead fracture or system upgrade (n=281). Patients were classified as systemic infection (n=88) or isolated pocket infection (n=68) based on the presence or absence of sepsis. Prospectively collected pre-operative procalcitonin (PCT), C-reactive protein (CRP), and white blood cell count (WBC) were compared between groups using Kruskal-Wallis and Dunn-Bonferroni tests. Results: PCT and WBC medians differed significantly between the systemic infection, the pocket infection, and the control groups (p