Angiotensin II AT 1A Receptor Antisense Lowers Blood Pressure in Acute 2-Kidney, 1-Clip Hypertension

Abstract — — To test the effectiveness of antisense oligonucleotides targeted to the angiotensin type 1A (AT 1A ) receptor mRNA on blood pressure reduction, the 2-kidney, 1-clip (2K1C) Goldblatt model of hypertension was studied in the acute phase of hypertension, when the peripheral renin-angiotens...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2001-09, Vol.38 (3), p.674-678
Main Authors: Galli, Sara M., Phillips, M. Ian
Format: Article
Language:English
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Summary:Abstract — — To test the effectiveness of antisense oligonucleotides targeted to the angiotensin type 1A (AT 1A ) receptor mRNA on blood pressure reduction, the 2-kidney, 1-clip (2K1C) Goldblatt model of hypertension was studied in the acute phase of hypertension, when the peripheral renin-angiotensin system is overactive. A single injection of AT 1A receptor antisense oligodeoxynucleotides significantly reduced systolic blood pressure for a period of 8 days in 2K1C rats after clipping, from 157.5±5 mm Hg on day 7 to 141.3±3.0 mm Hg on day 15 after clipping ( P
ISSN:0194-911X
1524-4563
DOI:10.1161/hy09t1.095207