Abstract P197: Differences in Renin-angiotensin System Components Expression in Tumoral and Normal Cell Lines

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 2016-09, Vol.68 (suppl_1)
• Main Authors: Passos-Silva, Danielle G, Oliveira, Marilene L, Silva, Felipe A, Oliveira, Samuel F, Etelvino, Gisele M, Sampaio, Walkyria O, Santos, Robson A
• Format: Article
• Language: English
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/hyp.68.suppl_1.p197

Abstract only Several reports have shown the actions of ACE/ AngII/AT1 axis in the development of malignancy and also predict that RAS inhibitors could potentiate cancer therapies. On the other hand, the alternative axis of renin angiotensin system, ACE2/Ang-(1-7)/Mas, demonstrated an anti-tumoral property. This anti-tumoral effect is not clear for the recently described components of RAS, Alamandine/MrgD. The aim of this work is to characterize the expression and the enzyme activities of the RAS components in different tumoral and normal cell lines. There was a significant increase in the expression of the components (ACE and AT2) related to the formation and actions of Ang II. ACE presented 1.8 A.U. and 1.4 A.U. in A549 and MIAPACA tumoral cell lines, respectively, in comparison with 0.6 A.U. of normal cell lines (VERO) (p< 0.05). On the other hand, there was reduction in ACE2 enzyme related to the formation of Angiotensin-(1-7) and Alamandine (0.25 A.U. in MIAPACA VS 1.7 A.U. in VERO, p