Abstract P278: Identification of Differentially Expressed Aortic Genes in Brown Norway Introgressed Chromosome 2 Segments into Hypertensive Dahl Salt Sensitive Rats

Abstract only Background: Rat chromosome (RNO) 2 introgression from normotensive Brown Norway (BN) rats into hypertensive Dahl salt sensitive (SS) background (consomic SB2) reduced vascular inflammation. We hypothesized that the BN-RNO2 contains genes that reduce vascular inflammation, which could b...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2017-09, Vol.70 (suppl_1)
Main Authors: Berillo, Olga, Ouerd, Sofiane, Huo, Ku-Geng, Rehman, Asia, Richer, Chantal, Sinnett, Daniel, Kwitek, Anne E, Paradis, Pierre, Schiffrin, Ernesto L
Format: Article
Language:English
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Summary:Abstract only Background: Rat chromosome (RNO) 2 introgression from normotensive Brown Norway (BN) rats into hypertensive Dahl salt sensitive (SS) background (consomic SB2) reduced vascular inflammation. We hypothesized that the BN-RNO2 contains genes that reduce vascular inflammation, which could be identified using microRNA (miRNA) and total RNA expression profiling in aorta of congenic rats containing different portions of BN-RNO2 on the SS background. Methods and Results: Twelve-to-13-week-old male SS rats and congenic rats containing the distal portion of BN-RNO2 (SB2a), the middle segment (SB2b) and the proximal segment (SB2e) on the SS background, fed a normal-salt diet, were studied. Systolic blood pressure (SBP) was measured by telemetry. SBP was lower in SB2a and SB2b but not SB2e compared to SS (125±3, 127±6, 138±4 vs 146±2 mm Hg, P
ISSN:0194-911X
1524-4563
DOI:10.1161/hyp.70.suppl_1.p278