Abstract P378: Dahl Salt-Sensitive Rats Exhibit Aberrant Renal Hemodynamic Responses to a High Salt Diet and Salt-Sensitive Hypertension as Compared to Consomic SS.BN1 Rats

Abstract only Altered renal vascular responses to a high salt diet have been proposed to contribute to salt-sensitive (SS) hypertension. The goals of this study were to assess: 1) SS hypertension and renal injury in Dahl SS vs. Brown-Norway (BN) and consomic SS.BN1 rats and 2) renal hemodynamics in...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2018-09, Vol.72 (Suppl_1)
Main Authors: Polichnowski, Aaron J, Potter, Jacqueline, Allen, Shannon, Dykes, Rhesa, Duffourc, Michelle, Williamson, Geoffrey A
Format: Article
Language:English
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Summary:Abstract only Altered renal vascular responses to a high salt diet have been proposed to contribute to salt-sensitive (SS) hypertension. The goals of this study were to assess: 1) SS hypertension and renal injury in Dahl SS vs. Brown-Norway (BN) and consomic SS.BN1 rats and 2) renal hemodynamics in conscious SS vs. SS.BN1 rats during consumption of a low and high salt diet. Systolic BP (24 hrs/day via telemetry), proteinuria and renal injury were assessed in 10 week old SS (n=9), BN (n=8) and SS.BN1 (n=8) rats during a 0.4% NaCl diet and for 3 weeks during a 4.0% NaCl diet. On a 0.4% NaCl diet, BP was different (P
ISSN:0194-911X
1524-4563
DOI:10.1161/hyp.72.suppl_1.P378