Abstract 091: Leptin-Thyroliberin Pathway in Left Ventricle Hypertrophy

Abstract only Cardiac TRH (cTRH) induces LVH and fibrosis. The adiponectin Leptin induces TRH in CNS. We hypothesized that in obesity, the increase of cTRH induced by hyperleptinemia is responsible for the LVH, mostly attributed to pressure load. We studied obese hyperleptinemic with mild hypertensi...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2019-09, Vol.74 (Suppl_1)
Main Authors: Aisicovich, Maia, Peres Diaz, Ludmila S, Schuman, Mariano L, Toblli, Jorge E, Landa, Maria S, García, Silvia I
Format: Article
Language:English
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Summary:Abstract only Cardiac TRH (cTRH) induces LVH and fibrosis. The adiponectin Leptin induces TRH in CNS. We hypothesized that in obesity, the increase of cTRH induced by hyperleptinemia is responsible for the LVH, mostly attributed to pressure load. We studied obese hyperleptinemic with mild hypertension Agouti mice, and found LVH with higher (p
ISSN:0194-911X
1524-4563
DOI:10.1161/hyp.74.suppl_1.091