Abstract P3003: miR-338-3p Down-Regulation Caused Up-Regulation of Alkaline Ceramidase 2 and Glutathione Peroxidase 3 mRNAs in Subcutaneous Small Arteries of Hypertensive Patients With Chronic Kidney Disease

Abstract only Background: Hypertension (HTN) and chronic kidney disease (CKD) are associated with vascular damage characterized by vascular remodeling and stiffening and endothelial dysfunction. miRNAs are small non-coding RNA that regulate gene expression by binding to their target messenger RNAs (...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2019-09, Vol.74 (Suppl_1)
Main Authors: Paradis, Pierre, Mahjoub, Nada, Huo, Ku-Geng, Berillo, Olga, Richer, Chantal, Fraulob-Aquino, Júlio C, Rehman, Asia, Briet, Marie, Boutouyrie, Pierre, Lipman, Mark L, Sinnett, Daniel, Schiffrin, Ernesto L
Format: Article
Language:English
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Summary:Abstract only Background: Hypertension (HTN) and chronic kidney disease (CKD) are associated with vascular damage characterized by vascular remodeling and stiffening and endothelial dysfunction. miRNAs are small non-coding RNA that regulate gene expression by binding to their target messenger RNAs (mRNAs), leading to mRNA degradation or translational repression. Their implication in vascular injury remains unclear. We aimed to identify differentially expressed (DE) miRs in small arteries of HTN and CKD human subjects to gain insight into pathophysiological molecular mechanisms in these conditions. Methods: Normotensive, HTN [systolic blood pressure (BP) >135 mmHg or diastolic BP of 85-115 mmHg with BpTRU] and CKD subjects (estimated glomerular filtration rate 1.5 and fold discovery rate
ISSN:0194-911X
1524-4563
DOI:10.1161/hyp.74.suppl_1.P3003